黄精在抑郁症中应用及其抗抑郁机理探讨.docVIP

黄精在抑郁症中应用及其抗抑郁机理探讨 　　摘要：黄精治疗抑郁症具有养血补心、滋阴柔肝、健脾补中、润肺生津、补肾益精功效，以调气机之升降，解气血之郁滞。其抗抑郁作用与调节脑内单胺类神经递质水平及其受体表达、调节突触可塑性及促进神经再生、调节机体微量元素等密切相关，并涉及抗疲劳、调节免疫、抗炎、调节血糖血脂及改善心脑循环等。本文通过文献分析，结合抑郁症病机，总结其配伍应用规律及抗抑郁机理。为中医临床治疗抑郁症提供思路。 　　关键词：黄精；抗抑郁；机理；综述 　　DOI：10.3969/j.issn.1005-5304.2015.12.040 　　中图分类号：R277.794 文献标识码：A 文章编号：1005-5304（2015）12-0127-03 　　Discussion on Application and Anti-depression Mechanism of Polygonati Rhizoma in the Treatment of Depression HUANG Shi-jing， PAN Ju-hua， WANG Yan-yun （Chinese Medicine Research and Development Center， Guang’anmen Hospital of China Academy of Chinese Medical Sciences， Beijing 100053， China） 　　Abstract：Polygonati Rhizoma has the effects of nourishing blood and tonifying heart， nourishing yin liver， tonifying spleen and strengthening the middle warmer， moistening lung and producing body liquid， nourishing kidney and strengthening the essence， with a purpose to regulate the rising and falling of qi function and treat qi-blood stasis for the treatment of depression. Its anti-depression effect is related to the regulation of monoamines neurotransmitter level in brain and the receptor expression， synaptic plasticity and promotion of nerve regeneration， and body microelement. It is also involved with resisting fatigue， immune regulation， anti inflammation， regulating blood fat and blood glucose， and improving cardio cerebral circulation. Based on depression pathogenesis， this article summarized the compatibility application laws and anti-depression mechanism through literature analysis， believed that in-depth study on the anti-depression effect of Polygonati Rhizoma will provide scientific references for TCM treatment for depression in clinic. 　　Key words：Polygonati Rhizoma；anti-depression；mechanism；review 　　抑郁症的主要病机与五脏虚损、气血不足有关[1]。黄精具有养血补心、滋阴养肝、健脾补中、润肺生津、补肾纳气功效，补五脏之虚损，充气血阴阳之不足，近年来用于抑郁症的治疗，取得较好效果。笔者根据近年来中医药治疗抑郁症的相关文献，结合抑郁症的发病机制，以探讨黄精治疗抑郁症的用药规律。 　　1 临床运用 　　1.1 润肺生津，降气解郁 　　肺为娇脏，位居上焦，喜润恶燥，最易受邪。黄精补气润肺、养阴润燥、降气解郁，可用于阴虚肺郁，悲 　　伤欲哭、失眠心悸之证，或伴阴虚咳嗽、