高频重复经颅磁模式刺激Broca区联合康复训练对孤独症谱系障碍患儿治疗作用.docVIP

高频重复经颅磁模式刺激Broca区联合康复训练对孤独症谱系障碍患儿治疗作用 　　[摘要] 目的 探讨高频重复经颅磁模式刺激镜像神经元区之一的Broca区对孤独症谱系障碍患儿的治疗作用。 方法 选取2014年6月～2015年10月徐州市儿童医院康复科收治的孤独症谱系障碍患儿53例为研究对象，按随机数字表法分成治疗组和对照组。对照组26例患儿采用传统的康复治疗模式，治疗组27例患儿在对照组治疗的基础上加入高频重复经颅磁模式刺激左侧Broca区，两组分别于治疗前及治疗4个月后采用孤独症儿童行为检查量表（ABC）、儿童孤独症评定量表（CARS）及小儿神经心理发育量表测评。 结果 4个月治疗后，治疗组患儿CARS总分[（31.03±5.79）分]、ABC总分[（73.33±15.05）分]、DQ值[（67.74±12.79）分]，以及ABC各因子评分中交往[（14.55±7.21）分]、躯体运动[（17.18±8.09）分]、语言[（13.14±8.36）分]评分均优于对照组患儿[（34.30±4.63）、（92.73.±14.14）、（61.19±10.10）、（19.69±5.56）、（21.84±6.75）、（18.53±7.05）分]，且均较治疗前显著改善，差异均有统计学意义（P 0.05）。 结论 高频重复经颅磁模式刺激Broca区联合康复训练对孤独症谱系障碍社会交往和刻板行为的改善有一定的促进作用。 　　[关键词] 镜像神经元；孤独症谱系障碍；高频经颅磁刺激；Broca区 　　[中图分类号] R730.55 [文献标识码] A [文章编号] 1673-7210（2016）06（c）-0113-04 　　[Abstract] Objective To investigate the effect of high-frequency repetitive transcranial magnetic stimulation combined with the therapeutical of rehabilitation training in Broca area based on the mirror neuron system for autism spectrum disorders. Methods Fifty-three children with autism spectrum disorders from June 2014 to October 2015 in Department of Rehabilitation， Childrens Hospital of Xuzhou City were selected， and they were divided into treatment group and control group according to random number table method， 26 cases of the control group were given traditional rehabilitation treatment mode， 27 cases of the treatment group were given high-frequency repetitive transcranial magnetic stimulation on the left side of the Broca area on the basis of rehabilitation training. The scores of Autism behavior checklist （ABC）， childhood autism rating scale （CARS） and the Gesell intellectual development scale were investigated before treatment and after 4 months treatment courses. Results After 4 months of treatment， CARS [（31.03±5.79） scores]， ABC [（73.33±15.05） scores]， DQ [（67.74±12.79） scores]， ABC social skills area [（14.55±7.21） scores]， the body movement area [（17.18±8.09） scores]， speech aera [（13.14±8.36） scores] of the treatment group were better than those