慢性髓系白血病首发血小板显著增多.docVIP

慢性髓系白血病首发血小板显著增多 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：慢性髓系白血病首发血小板显著增多 1 文2：赡养纠纷案件为何增多 10 一、赡养纠纷的原因 10 二、赡养纠纷的原因分析 11 三、赡养纠纷的对策与建议 12 参考文摘引言： 14 原创性声明（模板） 15 文章致谢（模板） 15 正文 慢性髓系白血病首发血小板显著增多 文1：慢性髓系白血病首发血小板显著增多 Chronic Myeloid Leukemia Oet with Marked Thrombocythemia Abstract This study was aimed to investigate the clinical，pathological and biological features of a special case of chronic myeloid leukemia (CML) with marked thrombocythemic oet. The morphological changes of cells were analyzed by using bone marrow smear and biopsy; Ph chromosome，a specific marker of CML，was assayed by conventional chromosomal analysis and fluorescence in situ hybridization，bcabl fusion gene was detected by revee tracription-polymerase chain reaction. The results indicated that CML mimicked essential thrombocythemia (ET) at presentation was relatively rare and might be misdiagnosed as ET，bone marrow smear and biopsy revealed，marked thrombocytosis and moderate leukocytosis; RT-PCR，FISH and conventional chromosomal analysis demotrated the existance of Ph chromosome and bcabl fusion special CML could progress into accelerated phase or blast megakaryocytes in Ph+ ET were smaller than normal ones and had typically hypolobulated round diagnosed as Ph+ ET might progress into CML and showed a high tendency to myelofibrosis and blastic traformation. It is concluded that the value of routine cytogenetical and molecular biological analysis in diagnosis for potential CML cases，which mimicked ET as in this presentation，is very distinctive，and the importance is magnified by the recent availability of imatinib，a specific inhibitor of the bcabl tyrosine kinase produced by the Philadelphia case of “ET” should be tested for the Philadelphia chromosome and bcabl tracript. Key words essential thrombocythemia； chronic myeloid leukemia； Ph chromosome； bcabl fusion gene 原发性血小板增多症（essential thrombocythemia，ET）和慢性髓系白血病（CML）属于骨髓增殖性疾病(myeloproliferative disorder，MPD)家族，但两者发病时的表现通常不