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2025-3-26Lungcancer
2025-3-26DefinitionBackgroundMalignantneoplasmarisingfrombronchialepithelium
2025-3-26Historicalnote100yearsago200casesreported1895Roentgendiagnosispossible1904Sauerbruchnegative-pressurecabin1912Daviesfirstlunglobectomy1941ZhangJizhengpneumonectomy
2025-3-26EpidemiologyMorbidity19thcenturyrarediseaseBefore1950sberisingRecent50yearsincreasedsharplyleadingcauseofcancerdeath
2025-3-26EtiologyOccupationalexposureLungcancerAirpollutionLunginfectionGeneticfactorsSmoking
2025-3-26DominantTumorsuppressorK-rasp53Mycfamily3pc-junrbGrowthfactorProteintyrosinephosphatase-γTGF-αnm23EGFRC-erbB2OncogenesandTumorsuppressorgenesReturn
2025-3-26PathologyLungcarcinogenesisAnatomiclocationHistologicalclassificationInvasionandMetastasisTNMstaging
2025-3-26LungcarcinogenesiscolumnarepitheliumsquamousmetaplasiacarcinomainsitumetastaticcarcinomainfiltratingcarcinomaInjuryRiskfactorsReturn
2025-3-26AnatomiclocationRightCentralPeripheralLeftUpperMiddlelowerUpperlowerReturn
2025-3-26ClassificationPercentageNSC75%Adenocarcinoma35%Squamouscellcarcinoma30%LargeCellcarcinoma10%SCC20%Carcinoids4%Rare1%HistologicalclassificationoflungcancerReturn
2025-3-26Return
2025-3-26Return
2025-3-26Return
2025-3-26InvasionandMetastasisLocalinfiltrateBronchiallumenDirectextension
2025-3-26LymphaticmetastasisPulmonaryhilumnodesCervicalnodesMediastinumnodesIntrapulmonarynodes
2025-3-26DistantmetastasisLungcancerBoneBrainOtherLiverPvReturn
2025-3-26TNMstagingT-PrimaryTumorN-LymphnodeM-Metastasis
2025-3-26PrimaryTumor
2025-3-26PrimaryTumor
2025-3-26Lymphnode
2025-3-26MetastasisM0—nodistantmetastasisM1—distantmetastasis
2025-3-26T1T2T3T4N0ⅠaⅠbⅡbⅢbN1ⅡaⅡbⅢaⅢbN2ⅢaⅢaⅢaⅢbN3ⅢbⅢbⅢbⅢbReturnTNMstaging
2025-3-26ClinicalpresentationEarlystageAdvancedstageParaneoplasticSyndromes
2025-3-26EarlystageNosymptomCoughPneumonicsymptomsHemoptysisDyspneaWheezingandStri
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