固肠胶囊治疗动物慢性溃疡性结肠炎及其机制研究.pdfVIP

·1350 · 现代药物与临床 Drugs Clinic 第 29 卷 第 12 期 2014 年 12 月 固肠胶囊治疗动物慢性溃疡性结肠炎及其机制研究 1 2 2 2* 1 1 1 陈芙蓉 ，刘 彤 ，商丹丹 ，江永萍 ，姜 溪 ，只德广 ，岳 南 1. 天津市新药安全评价研究中心，天津 300301 2. 天津中新药业集团股份有限公司 达仁堂制药厂，天津 300475 摘 要：目的 观察固肠胶囊对慢性溃疡性结肠炎的影响，并探讨其可能的作用机制。方法 采用复合型慢性溃疡性结肠炎、 脾虚型慢性溃疡性结肠炎实验模型，角叉菜胶致大鼠足肿胀、小鼠毛细血管通透性、大鼠棉球肉芽肿实验模型，观察固肠胶 囊对慢性溃疡性结肠炎的治疗作用。结果 固肠胶囊能明显降低复合型慢性溃疡性结肠炎的结肠指数（CI ）和疾病活动指数 （DAI ）、明显降低结肠IL-6 、IL-8 水平，明显减轻结肠黏膜病变；明显减少脾虚型慢性溃疡性结肠炎的溃疡面积和溃疡个数， 明显减轻结肠黏膜病变，明显降低棉球肉芽的质量，对大鼠足肿、小鼠毛细血管通透性无明显影响。结论 固肠胶囊通过降 低结肠 IL-6 、IL-8 水平，减轻慢性炎症，以达到治疗慢性溃疡性结肠炎的目的。 关键词：固肠胶囊；慢性溃疡性结肠炎；结肠指数；疾病活动指数 中图分类号：R285.5 ；R286.5 文献标志码：A 文章编号：1674 - 5515(2014)12 - 1350 - 07 DOI: 10.7501/j.issn.1674-5515.2014.12.005 Effect of Guchang Capsules on chronic ulcerative colitis in animals and its mechanism 1 2 2 2 1 1 1 CHEN Fu-rong , LIU Tong , SHANG Dan-dan , JIANG Yong-ping , JIANG Xi , ZHI De-guang , YUE Nan 1. Tianjin Centre for New Drug Safety Assessment and Research, Tianjin 300301, China 2. Darentang Pharmaceutical Factory, Tianjin Zhongxin Pharmaceutical Group Co., Ltd., Tianjin 300475, China Abstracts: Objective To investigate the effect and possible mechanisms of Guchang Capsules on chronic ulcerative colitis in rats and mice. Methods Complex type chronic ulcerative colitis, spleen deficient experimental model of chronic ulcerative colitis, carrageenan inducing foot swelling of rats, capillary permeability in mice, rat granuloma induced by cotton ball experiment mode were used, and effect of Guchang Capsules on chronic ulcerative colitis were studied. Results Guchang Capsules could obviously reduce colon index (CI) and disease activity index (DAI) of chronic ulcerative colitis, significant