消化-内科-1-总论.pptVIP

The NIH Human Microbiome Project 美国政府启动人类肠道菌群 基因序列研究项目(HMP) Source: Genome Research 2009;19:2317-2323 利用最新分子生态学技术，建立至少250例健康受试者的机体多部位微生物基因序列数据库； 研究不同情况下人体微生物菌群变化与人体健康和疾病之间的关系，寻找关键功能菌群； 为未来可研究提供人体微生物菌群基因数据库和最新研究方法学 功能性消化不良与胃轻瘫 HRM Diagnosis and Treatment Issues Don’t test for H.pylori unless you plan to treat it Where so ever you go, go with all your heart. * * To prove that the new bug could infect healthy people I drank some bacteri and became unwell. A little scientific experiment unlocked a lot of new information very rapidly, but also captured the imagination of the media for some reason. In this comic strip produced ny the Abbott company, here I am about to swig the brew. * * * * * * The self infection in 1984 fulfilled Koch’s postulates for H.pylori, proving that it caused gastritis. This shows a silver stain of the gastric mucosa with the acute infection. The black helical organisms are seen on damaged (brown) epithelial cells. Note that the cells do not have the normal transparent mucus content usually seen in the gastric epithelial layer. 消化系统疾病诊治总论 王化虹 北京大学第一医院消化内科 过去 感染为主 现在 肿瘤、免疫、功能性胃肠病 将来 特邀嘉宾 Berry Marshall 刘玉村院长应邀参加会议 Dr. Warren’s Initial Observation H.pylori(silver stain 1000x) First Attempt at Publication: 1983 Score = bottom 20% Dear Dr. Marshall, I regret that your research paper was not accepted for presentation... The number of abstracts we receive continues to increase and for this meeting 67 were submitted and we could only accept 56. An attempt to Fulfill Koch’s Postulates for Campylobacter pyloridis Med J. Aust 1985 I discovered that H.pylori can make you feel unwell! Day 8: The Infection Takes Hold Gastric Mucosa, Silver Stain, Day 10 益生菌提高Hp根除率机制 产生抑制Hp物质：amicoumacinA细菌素，破坏细胞壁 抑制Hp定植 抑制Hp尿素酶活性 抑制Hp感染后的炎症和免疫反应：减少IL-8分泌，降低胃内鸟氨酸脱羧酶的活性和多胺水平 改善微生态环境，增强免疫功能：增加sIgA的产生，上皮更新，调节黏膜血流分布，直接的非特异的抑菌活性 Future Applications? Flu Tetanus TB HIV Hep.C Malaria Therapeutic peptides Transjugular In