阿卡波糖联合辛伐他汀治疗高血脂合并脑卒中疗效及其对炎症状态影响.docVIP

阿卡波糖联合辛伐他汀治疗高血脂合并脑卒中疗效及其对炎症状态影响 　　[摘要] 目的 探讨阿卡波糖联合辛伐他汀治疗高血脂合并脑卒中的疗效及其对炎症状态的影响。 方法 选取高血脂合并脑卒中患者85例，按数字随机法分为实验组（n=55）和对照组（n=30）。对照组口服辛伐他汀和阿司匹林。实验组在对照组的基础上口服阿卡波糖。两组患者均治疗2个月。比较治疗前后两组患者的血脂水平、血清炎症因子水平和疗效。 结果 实验组和对照组治疗后血浆TC、TG、LDL-C、CRP、IL-6和TNF-α水平均降低，且实验组显著低于对照组，差异有统计学意义（P0.05）。实验组治疗有效率显著高于对照组（χ2=6.97，P0.05）。结论 阿卡波糖联合辛伐他汀可有效降低高血脂合并脑卒中患者的血脂和血清炎症因子水平，提高治疗有效率，值得临床推广应用。 　　[关键词] 阿卡波糖；辛伐他汀；高血脂；脑卒中；炎症因子 　　[中图分类号] R587.1 [文献标识码] B [文章编号] 1673-9701（2015）04-0076-03 　　[Abstract] Objective To investigate the curative effects and impact of acarbose and simvastatin on inflammatory condition of stroke patients with high blood lipid. Methods A total of 85 stroke patients with high blood lipid were selected and divided into experimental group（n=55） and control group（n=30）. The patients in experimental group were given acarbose besides the treatment like control group. The control group was given simvastatin and aspirin. All the patients were treated for 2 months. The blood lipid level， blood inflammatory factors level and curative effect of two groups were compared. Results The blood TC， TG， LDL-C， CRP， IL-6 and TNF-α levels of both group after treatment were much lower than before treatment， and the blood TC， TG， LDL-C， CRP， IL-6 and TNF-α levels of experimental group after treatment were significantly lower than that of the control group. The differences were statistically significant （P0.05）.The curative effect of experimental group was much higher than that of the control group （χ2=6.97， P0.05）. Conclusion Unitedly using acarbose and simcastatin in the treatment of stroke patients with high blood lipid can effectively lower the blood lipid and inflammatory factors level and increase the curative effect. It is worthy of clinical wide usage. 　　[Key words] Acarbose； Simvastatin； High blood lipid； Stroke； Inflammatory factors 　　高血脂和炎症因子水平是诱发脑卒中的危险因素之一[1]。高血脂亦会诱发胰岛素抵抗，随着我国人口老龄化问题的日益严重，脑卒中的发病率、致残率和致死率已跃居各疾病首位。低密度脂蛋白可进一步加重脑卒中患者的动脉内膜损伤，促进炎症因子等细胞因子的分泌[1]。高血脂和炎症因子水平是诱发脑卒中的危险因素之一[2]。高血脂还