联合检测血清CEA、CYFRA211、NSE在肺癌诊断中的临床价值.docxVIP

联合检测血清CEA、CYFRA21-1 NSE在肺癌诊断中的临床价 叶茜(山东大学第二医院250033) 【摘要】目的：研究血清癌胚抗原(carcino-embryonicantigen, CEA)细胞角 蛋白19片段(cytokeratin 19 fragment, CYFRA21J)、神经元特异性烯醇化 酶(neuronspecific enolase, NSE)对肺癌诊断的临床价值。方法：用电化学发光 免疫分析技术(ECLIA)法检测140例肺癌患者、189例肺部良性疾病患者的血清 CEA、CYFRA21-1 NSE 的表达水平。结果：1 .肺癌组血清 CEA、CYFRA21J、NSE 水平显著高于肺部良性疾病组(Plt;0.05)； 2.血清肿瘤标志物联合检测对肺癌诊 断的敏感性高于三项指标单独检测(Plt;0.05)； 3.血清肿瘤标志物的联合检测在 肺癌不同病理类型中阳性率存在显著性差异(Plt;0.05)o结论：血清CEA、 CYFRA21J、NSE是诊断肺癌较好的标志物，CEA + CYFRA21-1 + NSE联合检测对 肺癌的诊断有重要的临床价值，可明显提高肺癌诊断的敏感性。 【关键词】肺癌CEA CYFRA21-1 NSE肿瘤标志物 【中图分类号】R730.4 【文献标识码】A 【文章编号】2095-1752 (2013) 12-0032-02 The clinical value of combined detection of serum CEA^ CYFRA21-1^ NSE for diagnosis in patients with lung cancer by electrochem ilum inescence immuno-assay 【Abstract] Objective:To study the clinical significanee of detection of serum CEA (carcino-embryonicantigen)、 CYFRA21-1 (cytokeratin 19 fragment)、 NSE (neur on specific eno lase) for diag nosis in patie nts with lung can cer by ELICA (electrochem ilum inescenee immuno-assay).Methods:The serum levels of CEA^ CYFRA21-1 NSE in 140 patients with lung cancer,189 patients with benign lung diseases were measured by ELICA. Results: l.Levels of serum CEA、CYFRA21-1 NSE in lung cancer cases were significantly higher than those in benign lung diseases cases (Plt;0.05) .2. The sensitivity of combined detection of serum CEA CYFRA21-1 NSE was much higher than that detected separately for the diagonis of lung cancer .3.There was significantly differenee of the positive rate in combined detection of serum CEA CYFRA21-1 NSE in different types of lung cancer. Con clusi on:The combi ned detecti on of serum CEA CYFRA21 ?1、NSE was of im porta nt clinical value in the clin ical diag no sis,which might sign ifica ntly improve the sen sitivity for lung cancer detection,due to the obvious complementary of the 3 biomarkers. [Keywords] lung cancer CEA CYFRA21-1 NSE tumor marker 肺癌是最常见的恶性肿瘤，目前已成为肿瘤导致死亡的主要原因⑴。 在美国，尽管近十年来肺癌治疗技术不断进步，但是其五年生存率仍没有明显的 提高⑵，肺癌生存率的提高依赖