新诊断2型糖尿病患者血清磷脂脂肪酸谱特征分析.docVIP

·374 · · 论 著 · 新诊断2型糖尿病患者血清磷脂脂肪酸谱特征分析 朱麒钱，楼大钧，尤巧英，官莉莉，斯徐伟，张爱珍，李铎 【摘要】 目 的 分析新诊断2型糖尿病 (T2DM) 患者血清磷脂脂肪酸谱组分特征。方法 选择60例新诊断 T2DM 患者 (T2DM 组)和55例健康对照者(对照组),用高效气相色谱法测定并比较两组受检者的血清磷脂脂肪酸 谱组分。 结果 新诊断T2DM 组患者的饱和脂肪酸 (SFA) 总量较对照组显著升高〔(48.79±1.55)%与(42.58± 1.96)%〕,单不饱和脂肪酸 (MUFA) 总量较对照组显著降低〔(10.72±1.53)%与(12.09±1.32)%〕,多不饱和脂 肪酸 (PUFA) 亦较对照组显著降低〔(39.49±1.88)%与(45.33±1.96)%〕,差异均有统计学意义 (P0.01)。 结 论 新诊断T2DM 患者血清磷脂脂肪酸谱与健康者不同，前者SFA 总量高于健康者，而 MUFA、PUFA 总量低于健康 者。 【关键词】 糖尿病，2型；脂肪酸类；糖尿病膳食 【中图分类号】 R587.1 【文献标识码】 A 【文章编号】1007-9572(2010)02-0374-03 Fe atures of Serum Phospholipid Fatty Acids in Patients with Newly Diagnosed Type 2 Diabetes Mellitus ZHU Qi-qian, LOU Da-jun,YOU Qiao-ying,et al. Department of Endoerinology,Shaoxing Peoples Hospial,Shaoring 312000,China 【Abstract] Objective To analyze the features of serum phospholipid fatty spectrum in patients with newly diagnosed type 2 diabetes mellitus(T2DM). Methods Totally 60 patients with newly diagnosed T2DM,and 55 normal people as controls were enrolled. High performance gas chromatography was used to determine the levels of serum phospholipid fatty acid profile, and the results of the two groups were compared. Results The levels of saturated fatty acids(SFA) were significantly higher in newly diagnosed type 2 diabetes mellitus group than those in normal control group[(48.79±1.55)% vs(42.58±1.96)%,P 0.01].But the levels of monounsaturated fatty acids(MUFA)were lower in newly diagnosed type 2 diabetes mellitus group than those in normal control group [(10.72±1.53)% vs(12.09±1.32)%,P0.01],and the levels of polyunsaturated fatty acids(PUFA)were lower in newly diagnosed type 2 diabetes mellitus group than those in normal control group [(39.49± 1.88)% vs(45.33±1.96)%,P0.01].Conclusion Serum phospholipid fatty acid spectrum is different in patients with newly diagnosed T2DM from that in normal people. The total SFA is higher in the former than in the latter, but