舌鳞状细胞癌患者临床病理因素对预后的影响.docVIP

舌鳞状细胞癌患者临床病理因素对预后的影响1 王斌丁卫华张海云 ［摘要］目的分析评价舌鳞状细胞癌患者的临床病理因素对预后的彫响。方法 随访收集46例舌鳞状细胞癌患 者的临床资料（包括年龄、性别、病理分级、淋巴结转移、肿瘤大小、刖憾侵犯屮线、临床分期、手术治疗等）, 采用Kaplan-Meier法计算累积生存率，采用log-rank检验法进行单因素生存分析，应用Cox比例风险模型进 行多因素生存分析。结果46例舌鳞状细胞癌患者1年和3年生存率分别为76. 1%和58. 7%,单因素分析表明: 不同病理分级、有无淋巴结转移、肿瘤是否侵犯屮线、是否手术治疗对生存率的影响有统计学意义（PV0.05）, 多因素分析则只有定否手术治疗是影响预示的独立因素（戶＜0. 05）。结论以手术为主的综合治疗是改善舌鳞状 细胞癌患者预后的关键。 ［关键词］舌鳞状细胞癌；临床病理因素；预示 Impact of Clinicopathological Parameters of Patients with Tongue Squame?us Cell Carcinonna on the Impact of Clinicopathological Parameters of Patients with Tongue Squa me ?us Cell Carcinonna on the Prognosis WANG Bin, DING Wei-hua, ZHANG Ilai-yun (Department of Stomatology, The Zhangjiagang Hospital Affiliated to Suzhou University, Zhangjiagang 215600, China) [Abstract]Objective To evaluate the effects of clinicopathological parameters of patients with tongue squamous cell carci no ma(TSCC) on the prog nosis. Methods Clin ical follow-up data (age, gender, histological differentiation, lymphatic metastasis, Tumor size, invasion across the miclline of the tongue, clinical stage, surgical treatment) of 46 patients with TSCC were collected, survival rates were calculated by Kaplan-Meier method, Log-Rank test was used for univariate survival analysis, multivariate survival analysis was con clueted using the Cox proportional hazard model. Results The one-year and three-year survival rates were respectively 76. 1% and 58. 7%, in the univariate analysis, histological differentiatiom lymphatic metastasis, invasion across the midline of the tongue and surgical treatment were found to have signifiednt(P0?05) impact on the prognosis of patients with TSCC, Multivariate analysis showed that surgical treatmentwas the independent factor for the prognosisCPV0?05)?Conclusions It is crititical for surgical treatment to improve the prognosis of the patients with TSCC. [Key words] Tongue squamous cel 1 careinoma; Clinicopatholo百ical parameters; Prognosis 舌鳞状细胞癌（舌鳞癌）是口腔颌面部最为常见的恶性肿瘤［1］,它的发生不但严重影响患者的生存质最, 而且肓接