不同剂量辛伐他汀对不稳定型心绞痛患者血脂及血清淀粉样蛋白A影响.docxVIP

in and between groups were analyzed by t-test,P-value0.05(two-tailed)wasconsidered statistically significant.Results:1.Baseline levels of TC,LDL-C,SAA were significantly higher inpatients with UAP than those in control groups;2.The level of serum SAA is nodifference among different stenoses numbers of lesions;3.No significant diffirence oflipid levels were observed in the Simvastatin 20mg group before and aftertreatment.But levels of lipid levels were decreased more significantly in theSimvastatin 40mg group than 20mg group (P0.05);4. Compared to those beforetreatment, the level of levelsof SAA decreased in thetwo group .There wassignificant difference after treatment (P0.01). Comparing with 20mg/d simvastatingroup there was relatively lower levels of SAA on the 2 day in the 40mg/d simvastatingroup (P0.01);5.One factor correlation analysis shows the level of SAA is notcorrelated the base concentration level of serum TC and LDL-C(r＝0.133,P＝0.329；r＝0.196,P＝0.148；P0.O5 respectively);6. In two group the decrease ofSAA had no correlation to the levels of TC and LDL-C decreased.Conclusion：1. The baseline serum levels of SAA was higher in the UAPgroup；2.The level of serum SAA is not correlated the base concentration level ofserum lipid；3.The level of serum SAA is no difference among different stenosesnumbers of lesions；4. The use of simvastatin decreased significantly level of SAA. Itwas associated with the dose of simvastatin.The level of SAA decreased had nocorrelation to the level of LDL-C and TC. The use of higher dose simvastatin in thepatients of UAP may modulate lipids and benefit to atherosclerotic plaquestabilization.Postgraduate: Hong Ya-li (Department of Cardiology)Directed by:Prof. LEI Chang-chengKey words：Unstable angina pectoris Simvastatin Lipids in blood Serumamyloid A8前言急性冠状动脉综合征(acute coronary syndrome,ACS)发病主要是由于冠状动脉在斑块破裂的基础上诱发急性血栓形成，根据部分栓塞、微栓塞和完全栓塞，临床可表现为不稳定型心绞痛(unstable angina pectoris，UAP)、非 ST 段抬高性心肌梗死(non-ST-elevated-myocardial-infarction，NSTEMI)、ST