果糖二磷酸钠联合高压氧治疗颅脑损伤对患者血清NSE影响及效果评价.docVIP

果糖二磷酸钠联合高压氧治疗颅脑损伤对患者血清NSE影响及效果评价 　　[摘要] 目的 观察果糖二磷酸钠联合高压氧治疗颅脑损伤的效果和对患者血清中神经特异性烯醇化酶（neuron specific enolase，NSE）的影响。 方法 将82例颅脑损伤患者随机分为对照组和治疗组两组各41例，治疗组除予常规治疗外再予果糖二磷酸钠联合高压氧治疗，对照组给予常规治疗，比较两组治疗前后血清中神经特异性烯醇化酶变化情况，并观察两组治疗前后GCS评分及伤后6个月GOS评分改善情况。 结果 治疗组总有效率90.2%，对照组总有效率70.7%，差异有统计学意义（P0.05）；治疗组治疗后NSE水平较治疗前下降均比对照组更为明显（P0.05）。 结论 果糖二磷酸钠联合高压氧治疗颅脑损伤患者的临床效果明显，并可明显降低颅脑损伤患者血清NSE水平，明显改善预后。 　　[关键词] 高压氧；果糖二磷酸钠；颅脑损伤；神经特异性烯醇化酶 　　[中图分类号] R722.12 [文献标识码] B [文章编号] 1673-9701（2014）17-0055-04 　　Effect of fructose sodium diphosphate combined with hyperbaric oxygen therapy in treating craniocerebral injury evaluated by serumal neuron specific enolase 　　JIN Menghao1 WANG Feng1 HE Zhiyong2 　　1.Department of Neurosurgery， Integrative Medicine Hospital of Wenzhou City， Wenzhou 325000， China； 2.Neurology， the Affilliated Second Hospital of Wenzhou Medical College，Wenzhou 325000，China 　　[Abstract] Objective To investigate the clinical effect of fructose sodium diphosphate （FDP） combined with hyperbaric oxygen therapy in treating craniocerebral injury which was evaluated by serumal neuron specific enolase （NSE）. Methods All 82 patients diagnozed with craniocerebr injury were randomly divided into two groups： control group， which received routine treatment； Experiment group， which received additional FDP combined with hyperbaric oxygen therapy. The clinical outcome were evaluated by serumal NSE， Glasgow Coma Scale（GCS） pre- and post-treatment as well as Clasgow Outcome Score（GOS） 6 months after injury. Results The total effective rate of experimental group and control group was 90.2% and 70.7% respectively（P0.05）. The decline of NSE after treatment was more obvious in experiment group than that in control group （P0.05）. Conclusion FDP combined with hyperbaric oxygen therapy could significantly reduce serumal NSE and enhance the prognosis of routine treatment of craniocerebral injury. 　　[Key words] Hyperbaric oxygen；Fructose sodium diphosphate；Traumatic brain injury；Neuron specific enolase 　　目